Blar i Bergen Open Research Archive på forfatter "Brekken, Rolf A."

Viser treff 1-2 av 2

    • AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells 

      Li, Huiyu; Liu, Zhida; Liu, Longchao; Zhang, Hongyi; Han, Chuanhui; Girard, Luc; Park, Hyunsil; Zhang, Anli; Dong, Chunbo; Ye, Jianfeng; Rayford, Austin James; Peyton, Michael; Li, Xiaoguang; Avila, Kimberley; Cao, Xuezhi; Hu, Shuiqing; Alam, Md Maksudul; Akbay, Esra A.; Solis, Luisa M.; Behrens, Carmen; Hernandez-Ruiz, Sharia; Lu, Wei; Wistuba, Ignacio; Heymach, John V.; Chisamore, Michael; Micklem, David Robert; Gabra, Hani; Gausdal, Gro; Lorens, James; Li, Bo; Fu, Yang-Xin; Minna, John D.; Brekken, Rolf A. (Journal article; Peer reviewed, 2022)
      Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas ...

    • PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression 

      Sui, Lufei; Wang, Suming; Ganguly, Debolina; El Rayes, Tyler P.; Askeland, Cecilie; Børretzen, Astrid; Sim, Danielle; Halvorsen, Ole Johan; Knutsvik, Gøril; Arnes, Jarle; Aziz, Sura Mohammed; Haukaas, Svein Andreas; Foulkes, William D.; Bielenberg, Diane R.; Ziemys, Arturas; Mittal, Vivek; Brekken, Rolf A.; Akslen, Lars Andreas; Watnick, Randolph (Journal article; Peer reviewed, 2022)
      The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ...